HDAC7

Across TCGA cell cohorts, HDAC7 mutation is significantly associated with the RNA expression of many other genes, with 221 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDAC7-associated genes across cancer lineages are PRR30, TNNT3, and DSG1. Each is linked with HDAC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC7-to-partner and partner-to-HDAC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR30 grouped by HDAC7-low versus HDAC7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC7→partner) and Y-score (partner→HDAC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRR30 →	+0.015	+3.684	<.001	.004	3	2
CNS	TNNT3 →	+0.820	+3.555	.003	.005	3	1
CNS	DSG1 →	+0.172	+4.204	<.001	.001	3	1
CNS	HEMGN →	+0.013	+3.398	.004	.004	3	1
CNS	GPHA2 →	+0.352	+3.000	<.001	.007	3	1
CNS	CDCP2 →	+0.017	+3.273	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 221 associations by consensus.

PRR30 by HDAC7 expression — BLOOD_Leukemia

Explore this box plot interactively →