HDAC6

Across TCGA patient cohorts, HDAC6 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,391 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HDAC6-associated proteins across cancer lineages are VEZF1, NONO, and SAMSN1. Each is linked with HDAC6 in more than 4 cancer types. Because this analysis shows association rather than direction, both HDAC6-to-partner and partner-to-HDAC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDAC6 versus VEZF1 in GBM, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC6→partner) and Y-score (partner→HDAC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VEZF1 →	+0.454	+0.425	<.001	<.001	3	5
GBM	NONO →	+0.174	+0.242	<.001	<.001	3	5
CCRCC	SAMSN1 →	-0.550	-0.630	<.001	<.001	3	5
COAD	HUWE1 →	+0.290	+0.717	<.001	<.001	3	5
LUAD	RPL26 →	-0.595	-0.458	<.001	<.001	3	4
GBM	STAG2 →	+0.290	+0.260	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,391 associations by consensus.

HDAC6 vs VEZF1 — GBM

Explore this scatter interactively →