HDAC6

Across TCGA patient cohorts, HDAC6 protein abundance is significantly associated with the RNA expression of many other genes, with 11,164 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HDAC6-associated genes across cancer lineages are ZNF674, RHOXF1-AS1, and MICALL1. Each is linked with HDAC6 in more than 3 cancer types. Because this analysis shows association rather than direction, both HDAC6-to-partner and partner-to-HDAC6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDAC6 versus ZNF674 in HNSC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC6→partner) and Y-score (partner→HDAC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF674 →	+0.388	+0.176	.003	<.001	2	4
UCEC	RHOXF1-AS1 →	+0.855	+0.186	<.001	.002	3	3
LSCC	MICALL1 →	-0.706	-0.180	.001	.001	3	3
LSCC	IMPDH1 →	-0.618	-0.207	<.001	.001	3	3
CCRCC	CUBN →	+1.484	+0.169	<.001	<.001	3	3
CCRCC	SLC5A9 →	+0.828	+0.252	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,164 associations by consensus.

HDAC6 vs ZNF674 — HNSC

Explore this scatter interactively →