HDAC6

Across TCGA patient cohorts, HDAC6 mutation is significantly associated with the RNA expression of many other genes, with 6,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC6-associated genes across cancer lineages are PMM2P1, SERINC4, and BCAS2P3. Each is linked with HDAC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both HDAC6-to-partner and partner-to-HDAC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PMM2P1 grouped by HDAC6-low versus HDAC6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC6→partner) and Y-score (partner→HDAC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PMM2P1 →	+0.055	+4.757	<.001	.004	3	3
STAD	SERINC4 →	+0.009	+2.976	.006	.006	3	3
HNSC	BCAS2P3 →	+0.107	+3.952	<.001	.005	3	3
UCEC	PLA2G3 →	+0.558	+1.754	<.001	<.001	3	3
UCEC	TXN →	+0.402	+1.739	<.001	<.001	3	3
KIRC	CSGALNACT2P2 →	+0.150	+4.090	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,215 associations by consensus.

PMM2P1 by HDAC6 expression — CESC

Explore this box plot interactively →