HDAC6

Across TCGA patient cohorts, HDAC6 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC6-associated genes across cancer lineages are PCNA, ASNS, and C-Raf. Each is linked with HDAC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both HDAC6-to-partner and partner-to-HDAC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by HDAC6-low versus HDAC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC6→partner) and Y-score (partner→HDAC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.219	+1.736	<.001	<.001	3	3
UCEC	ASNS →	+0.324	+1.459	<.001	.009	3	3
COAD	C-Raf →	+0.170	+2.841	.025	.033	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.456	-3.000	.022	.036	3	2
SKCM	Stathmin →	+0.282	+2.832	.005	.034	3	2
UCEC	A-Raf_pS299 →	-0.126	-2.137	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

PCNA by HDAC6 expression — UCEC

Explore this box plot interactively →