HDAC6

Across TCGA cell cohorts, HDAC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,734 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HDAC6-associated GO terms across cancer lineages are Tubulin deacetylation, Positive regulation of intracellular steroid hormone receptor signaling pathway, and Type 2 mitophagy. Each is linked with HDAC6 in more than 18 cancer types. Because this analysis shows association rather than direction, both HDAC6-to-partner and partner-to-HDAC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tubulin deacetylation grouped by HDAC6-low versus HDAC6-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC6→partner) and Y-score (partner→HDAC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Tubulin deacetylation →	+0.164	+0.890	<.001	<.001	3	19
LARGE_INTESTINE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.153	+0.952	<.001	<.001	3	18
LUNG_NSCLC_LUAD	Type 2 mitophagy →	+0.228	+1.023	<.001	<.001	3	17
LUNG_SCLC	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.188	+0.866	<.001	<.001	3	17
STOMACH	Negative regulation of myoblast fusion →	+0.142	+1.083	.001	<.001	3	15
LIVER	Negative regulation of hydrogen peroxide metabolic process →	+0.308	+1.128	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,734 associations by consensus.

Tubulin deacetylation by HDAC6 expression — OESOPHAGUS

Explore this box plot interactively →