HDAC6

Across TCGA cell cohorts, HDAC6 mutation is significantly associated with the RNA expression of many other genes, with 151 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDAC6-associated genes across cancer lineages are GH2, KRTAP1-4, and GRIFIN. Each is linked with HDAC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC6-to-partner and partner-to-HDAC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GH2 grouped by HDAC6-low versus HDAC6-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC6→partner) and Y-score (partner→HDAC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GH2 →	+0.054	+3.247	<.001	.003	3	2
OESOPHAGUS	KRTAP1-4 →	+0.143	+4.906	<.001	.006	3	1
LUNG_SCLC	GRIFIN →	+0.117	+5.029	<.001	.006	3	1
STOMACH	NEUROD6 →	+0.012	+3.152	<.001	.002	3	1
OVARY	PPIAL4D →	+0.101	+2.841	.001	.009	3	1
BLOOD_Leukemia	SLC32A1 →	+0.390	+3.223	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 151 associations by consensus.

GH2 by HDAC6 expression — STOMACH

Explore this box plot interactively →