HDAC5

Across TCGA pan-cancer cohorts, HDAC5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HDAC5 data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HDAC5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HDAC5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

UCEC, CCRCC, and LUAD are the cancer types where HDAC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	0.433	1.000	.007	28	view →
CCRCC	DFS	Quartile	III,IV	0.812	0.304	.002	23	view →
LUAD	DFS	Tertile	All	0.841	0.603	.006	17	view →
PDAC	OS	Median	IV	0.951	0.381	.006	15	view →
OV	DFS	Median	All	0.564	0.971	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HDAC5–UCEC (OS)

Open the UCEC breakdown →