HDAC5

Across TCGA patient cohorts, HDAC5 protein abundance is significantly associated with the RNA expression of many other genes, with 12,412 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible HDAC5-associated genes across cancer lineages are CBX7, PRX, and C1QTNF7. Each is linked with HDAC5 in more than 5 cancer types. Because this analysis shows association rather than direction, both HDAC5-to-partner and partner-to-HDAC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDAC5 versus CBX7 in UCEC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC5→partner) and Y-score (partner→HDAC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CBX7 →	+0.565	+0.463	<.001	<.001	3	5
CCRCC	PRX →	+0.580	+0.196	<.001	<.001	3	5
CCRCC	C1QTNF7 →	+0.864	+0.200	<.001	<.001	3	5
CCRCC	SVEP1 →	+1.156	+0.234	<.001	.001	3	5
HNSC	ZNF540 →	+0.651	+0.324	<.001	<.001	2	6
BRCA	PLAC9 →	+1.073	+0.270	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,412 associations by consensus.

HDAC5 vs CBX7 — UCEC

Explore this scatter interactively →