HDAC5

Across TCGA patient cohorts, HDAC5 mutation is significantly associated with the RNA expression of many other genes, with 4,381 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC5-associated genes across cancer lineages are NF2, COX15, and KIAA1522. Each is linked with HDAC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both HDAC5-to-partner and partner-to-HDAC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by HDAC5-low versus HDAC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC5→partner) and Y-score (partner→HDAC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.552	+2.425	<.001	<.001	3	3
UCEC	COX15 →	+0.472	+2.716	<.001	<.001	3	3
UCEC	KIAA1522 →	+0.403	+1.506	.002	.002	3	3
UCEC	POC1A →	+0.454	+2.807	.003	.003	3	3
UCEC	C4orf3 →	+0.453	+2.179	<.001	<.001	3	3
UCEC	PRDX3 →	+0.526	+3.202	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,381 associations by consensus.

NF2 by HDAC5 expression — UCEC

Explore this box plot interactively →