HDAC5

Across TCGA patient cohorts, HDAC5 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC5-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and MSH2. Each is linked with HDAC5 in more than 2 cancer types. Because this analysis shows association rather than direction, both HDAC5-to-partner and partner-to-HDAC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HDAC5-low versus HDAC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC5→partner) and Y-score (partner→HDAC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.583	-2.201	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.617	+3.186	<.001	.009	3	2
UCEC	MSH2 →	-0.246	-2.674	.001	.005	3	2
UCEC	p62 Lck ligand →	+0.235	+1.916	.031	.009	3	2
UCEC	PDCD4 →	-0.537	-1.321	<.001	.029	3	2
UCEC	Rad50 →	-0.258	-2.102	.001	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ATM by HDAC5 expression — UCEC

Explore this box plot interactively →