HDAC5

Across TCGA cell cohorts, HDAC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,198 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HDAC5-associated GO terms across cancer lineages are Macroautophagy, Negative regulation of syncytium formation by plasma membrane fusion, and Negative regulation of respiratory burst involved in inflammatory response. Each is linked with HDAC5 in more than 13 cancer types. Because this analysis shows association rather than direction, both HDAC5-to-partner and partner-to-HDAC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macroautophagy grouped by HDAC5-low versus HDAC5-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC5→partner) and Y-score (partner→HDAC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Macroautophagy →	+0.070	+1.260	.009	.006	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of syncytium formation by plasma membrane fusion →	+0.113	+1.031	<.001	<.001	3	13
BLOOD_Lymphoma	Negative regulation of respiratory burst involved in inflammatory response →	+0.122	+0.858	<.001	<.001	3	13
BLOOD_Lymphoma	Negative regulation of respiratory burst →	+0.122	+0.858	<.001	<.001	3	13
STOMACH	Process utilizing autophagic mechanism →	+0.072	+1.295	.008	.002	3	13
STOMACH	Autophagy →	+0.072	+1.295	.008	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,198 associations by consensus.

Macroautophagy by HDAC5 expression — STOMACH

Explore this box plot interactively →