HDAC5

Across TCGA cell cohorts, HDAC5 mutation is significantly associated with the RNA expression of many other genes, with 108 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDAC5-associated genes across cancer lineages are ELOA3DP, LRRC53, and BMP15. Each is linked with HDAC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC5-to-partner and partner-to-HDAC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by HDAC5-low versus HDAC5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC5→partner) and Y-score (partner→HDAC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ELOA3DP →	+0.189	+4.007	<.001	.002	3	2
URINARY_TRACT	LRRC53 →	+0.184	+3.632	.003	.001	3	1
BREAST	BMP15 →	+0.012	+4.781	<.001	.003	3	1
BREAST	DUSP29 →	+0.440	+4.781	<.001	.003	3	1
BREAST	CLEC6A →	+0.018	+4.672	<.001	.002	3	1
BREAST	DEFA1 →	+0.220	+4.199	.009	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 108 associations by consensus.

ELOA3DP by HDAC5 expression — BLOOD_Leukemia

Explore this box plot interactively →