HDAC4

Across TCGA patient cohorts, HDAC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,594 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HDAC4-associated proteins across cancer lineages are HDAC4_S467, HDAC4_S565, and ILKAP. Each is linked with HDAC4 in more than 6 cancer types. Because this analysis shows association rather than direction, both HDAC4-to-partner and partner-to-HDAC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDAC4 versus HDAC4_S467 in UCEC, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC4→partner) and Y-score (partner→HDAC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HDAC4_S467 →	+0.519	+0.697	<.001	<.001	3	7
HNSC	HDAC4_S565 →	+0.547	+0.681	<.001	<.001	3	7
LSCC	ILKAP →	+0.341	+0.781	<.001	<.001	3	6
LSCC	HDAC4_S632 →	+0.664	+0.774	<.001	.005	3	6
LSCC	MAP1B_S937 →	+1.584	+0.578	<.001	<.001	3	4
GBM	RPS6 →	-0.367	-0.349	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,594 associations by consensus.

HDAC4 vs HDAC4_S467 — UCEC

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