HDAC4

Across TCGA patient cohorts, HDAC4 protein abundance is significantly associated with the RNA expression of many other genes, with 10,974 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HDAC4-associated genes across cancer lineages are FARP2, PTN, and PRRX1. Each is linked with HDAC4 in more than 4 cancer types. Because this analysis shows association rather than direction, both HDAC4-to-partner and partner-to-HDAC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HDAC4 versus FARP2 in BRCA, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC4→partner) and Y-score (partner→HDAC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FARP2 →	+0.433	+0.229	<.001	<.001	3	5
BRCA	PTN →	+1.621	+0.292	<.001	<.001	3	4
UCEC	PRRX1 →	+1.509	+0.474	<.001	<.001	3	4
COAD	DPT →	+1.185	+0.329	.006	.001	3	4
BRCA	GTDC1 →	+0.351	+0.230	.001	<.001	3	4
LSCC	FAM117B →	+0.911	+0.201	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,974 associations by consensus.

HDAC4 vs FARP2 — BRCA

Explore this scatter interactively →