HDAC4

Across TCGA patient cohorts, HDAC4 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC4-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and 4E-BP1. Each is linked with HDAC4 in more than 4 cancer types. Because this analysis shows association rather than direction, both HDAC4-to-partner and partner-to-HDAC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HDAC4-low versus HDAC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC4→partner) and Y-score (partner→HDAC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.539	+1.604	<.001	.001	3	5
COAD	eIF4E →	+0.260	+3.025	.005	.019	3	4
UCEC	4E-BP1 →	+0.305	+1.478	<.001	<.001	3	4
LUAD	Cyclin-B1 →	+0.505	+3.169	.024	.018	3	3
LUSC	eEF2K →	+0.399	+2.331	.010	.019	3	3
UCEC	mTOR_pS2448 →	-0.079	-1.082	.035	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Caspase-7-cleavedD198 by HDAC4 expression — UCEC

Explore this box plot interactively →