HDAC4

Across TCGA cell cohorts, HDAC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,794 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HDAC4-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Regulation of protein sumoylation, and Negative regulation of gene expression, epigenetic. Each is linked with HDAC4 in more than 13 cancer types. Because this analysis shows association rather than direction, both HDAC4-to-partner and partner-to-HDAC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by HDAC4-low versus HDAC4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC4→partner) and Y-score (partner→HDAC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.115	+1.140	<.001	<.001	3	14
LUNG_SCLC	Regulation of protein sumoylation →	+0.110	+0.676	<.001	<.001	3	14
LARGE_INTESTINE	Negative regulation of gene expression, epigenetic →	+0.057	+0.923	<.001	.005	3	14
SOFT_TISSUE	Protein localization to chromatin →	+0.100	+1.327	<.001	<.001	3	13
STOMACH	Regulation of nucleotide-excision repair →	+0.131	+1.018	.008	.003	2	14
BONE	Subtelomeric heterochromatin formation →	+0.117	+0.690	.002	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,794 associations by consensus.

Viral translational termination-reinitiation by HDAC4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →