HDAC4

Across TCGA cell cohorts, HDAC4 mutation is significantly associated with the RNA expression of many other genes, with 772 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDAC4-associated genes across cancer lineages are NARS1, MSH4, and DEPDC5. Each is linked with HDAC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both HDAC4-to-partner and partner-to-HDAC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NARS1 grouped by HDAC4-low versus HDAC4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC4→partner) and Y-score (partner→HDAC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NARS1 →	+0.676	+2.767	.001	<.001	3	3
LARGE_INTESTINE	MSH4 →	+0.201	+2.422	<.001	<.001	3	3
LARGE_INTESTINE	DEPDC5 →	+0.429	+1.808	.006	.001	3	2
LARGE_INTESTINE	TXN2 →	+0.381	+1.544	.007	.008	3	2
LARGE_INTESTINE	DDHD1 →	+0.575	+2.459	.003	.003	3	2
LARGE_INTESTINE	C1QBP →	+0.577	+1.544	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 772 associations by consensus.

NARS1 by HDAC4 expression — LARGE_INTESTINE

Explore this box plot interactively →