Across TCGA pan-cancer cohorts, HDAC2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HDAC2 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HDAC2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HDAC2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

HNSC, LSCC, and COAD are the cancer types where HDAC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.372	1.000	.022	33	view →
LSCC	DFS	Quartile	All	0.870	0.562	.015	14	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
PDAC	DFS	Median	All	0.861	0.727	.016	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: HDAC2 tumor-vs-normal RNA expression · all HDAC2 data types