Across TCGA patient cohorts, HDAC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,614 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HDAC2-associated proteins across cancer lineages are CDC40, CDC5L, and HDAC2_S394. Each is linked with HDAC2 in more than 7 cancer types. Because this analysis shows association rather than direction, both HDAC2-to-partner and partner-to-HDAC2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC2→partner) and Y-score (partner→HDAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDC40 →	+0.405	+0.802	<.001	<.001	3	8
LSCC	CDC5L →	+0.232	+0.539	<.001	<.001	3	8
LSCC	HDAC2_S394 →	+0.357	+0.521	<.001	<.001	3	8
LSCC	STMN1 →	+0.498	+0.533	<.001	<.001	3	7
LSCC	SYNCRIP →	+0.303	+0.648	<.001	<.001	3	7
GBM	SF3B1 →	+0.180	+0.490	.006	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,614 associations by consensus.

Exploration

HDAC2 survival (RNA) · tumor vs normal (RNA) · all HDAC2 data types