Across TCGA patient cohorts, HDAC2 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC2-associated genes across cancer lineages are Notch1, EGFR_pY1068, and eIF4G. Each is linked with HDAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC2-to-partner and partner-to-HDAC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC2→partner) and Y-score (partner→HDAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.275	+2.700	<.001	.006	3	2
UCEC	EGFR_pY1068 →	-0.319	-2.700	.004	.006	3	1
UCEC	eIF4G →	+0.315	+3.169	.024	.019	3	1
UCEC	Gab2 →	+0.447	+2.000	.005	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.182	-1.986	.016	.032	3	1
UCEC	Ku80 →	+0.250	+2.013	.018	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

HDAC2 survival (RNA) · tumor vs normal (RNA) · all HDAC2 data types