Across TCGA cell cohorts, HDAC2 mutation is significantly associated with the drug of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HDAC2-associated genes across cancer lineages are Bosutinib, Doramapimod, and ULK1_4989. Each is linked with HDAC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC2-to-partner and partner-to-HDAC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC2→partner) and Y-score (partner→HDAC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Bosutinib →	+0.462	+2.807	.008	.046	3	1
LARGE_INTESTINE	Doramapimod →	+0.398	+2.807	.006	.046	3	1
LARGE_INTESTINE	ULK1_4989 →	+0.606	+3.064	.043	.009	3	1
LARGE_INTESTINE	Mitoxantrone →	+0.677	+2.710	.011	.027	3	1
LARGE_INTESTINE	Fulvestrant →	+0.335	+2.684	.031	.035	3	1
LARGE_INTESTINE	123829 →	+0.759	+3.064	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

HDAC2 survival (RNA) · tumor vs normal (RNA) · all HDAC2 data types