Across TCGA pan-cancer cohorts, HDAC2-AS2 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of HDAC2-AS2’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where HDAC2-AS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HDAC2-AS2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
COAD, KIRC, and BLCA are the cancer types where HDAC2-AS2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HDAC2-AS2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.