HDAC11

Across TCGA pan-cancer cohorts, HDAC11 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HDAC11 data layer compared with 20 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HDAC11 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HDAC11 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

SKCM, OV, and READ are the cancer types where HDAC11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.138	0.871	<.001	31	view →
OV	DFS	Median	III,IV	1.000	0.147	.006	24	view →
READ	DFS	Median	All	0.255	0.844	.004	21	view →
BRCA	OS	Median	III,IV	0.165	0.833	<.001	12	view →
HNSC	DFS	Median	II,III,IV	0.194	0.661	.031	9	view →
KIRP	OS	Median	All	0.635	0.903	.022	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
KICH	DFS	Median	All	0.425	0.847	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HDAC11–SKCM (OS)

Open the SKCM breakdown →