HDAC11

Across TCGA pan-cancer cohorts, HDAC11 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HDAC11 data layer compared with 20 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HDAC11 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated HDAC11 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and GBM are the cancer types where HDAC11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	1.000	0.451	.016	15	view →
PDAC	DFS	Median	III,IV	0.708	0.294	.023	14	view →
GBM	OS	Quartile	All	0.224	0.642	.003	6	view →
UCEC	DFS	Tertile	All	0.957	0.768	.042	4	view →
LSCC	DFS	Median	All	0.614	0.928	.026	1	view →
LUAD	DFS	Quartile	All	0.913	0.520	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HDAC11–CCRCC (OS)

Open the CCRCC breakdown →