HDAC11

Across TCGA patient cohorts, HDAC11 mutation is significantly associated with the RNA expression of many other genes, with 1,188 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC11-associated genes across cancer lineages are ZNF519P4, TRAV31, and RNA5SP124. Each is linked with HDAC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC11-to-partner and partner-to-HDAC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF519P4 grouped by HDAC11-low versus HDAC11-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC11→partner) and Y-score (partner→HDAC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF519P4 →	+0.340	+5.070	<.001	.008	3	2
BRCA	TRAV31 →	+0.147	+5.721	<.001	.003	3	2
UCEC	RNA5SP124 →	+0.345	+2.067	.001	.005	3	2
UCEC	RNU6-192P →	+0.329	+3.152	<.001	.001	3	2
UCEC	HMGB3P3 →	+0.172	+2.146	<.001	.006	3	2
UCEC	RNA5SP420 →	+0.613	+2.092	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,188 associations by consensus.

ZNF519P4 by HDAC11 expression — BRCA

Explore this box plot interactively →