HDAC11

Across TCGA patient cohorts, HDAC11 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HDAC11-associated genes across cancer lineages are CMP, Macrophages, and pDC. Each is linked with HDAC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC11-to-partner and partner-to-HDAC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CMP grouped by HDAC11-low versus HDAC11-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC11→partner) and Y-score (partner→HDAC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CMP →	+0.063	+2.396	.001	.037	3	2
COAD	Macrophages →	+0.022	+3.288	.041	.041	3	2
UCEC	pDC →	+0.051	+2.202	.012	.033	3	2
UCEC	Endothelial cells →	-0.032	-1.657	.045	.045	3	1
UCEC	Myocytes →	+0.038	+3.076	.004	.016	3	1
UCEC	NKT →	-0.098	-2.989	.030	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

CMP by HDAC11 expression — SKCM

Explore this box plot interactively →