HDAC11

Across TCGA cell cohorts, HDAC11 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible HDAC11-associated genes across cancer lineages are CFHR2 and ASB17. Each is linked with HDAC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC11-to-partner and partner-to-HDAC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by HDAC11-low versus HDAC11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC11→partner) and Y-score (partner→HDAC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.076	+6.022	<.001	.001	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CFHR2 by HDAC11 expression — LARGE_INTESTINE

Explore this box plot interactively →