HDAC11

Across TCGA cell cohorts, HDAC11 mutation is significantly associated with the mutation status of many other genes, with 1,293 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible HDAC11-associated genes across cancer lineages are TBX2, PCSK9, and SSH3. Each is linked with HDAC11 in more than 3 cancer types. Because this analysis shows association rather than direction, both HDAC11-to-partner and partner-to-HDAC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX2 grouped by HDAC11-low versus HDAC11-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC11→partner) and Y-score (partner→HDAC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TBX2 →	+4.345	+4.345	<.001	<.001	1	4
OVARY	PCSK9 →	+4.930	+3.977	.001	.001	1	3
OVARY	SSH3 →	+4.930	+3.977	.001	.001	1	3
OVARY	RPS6KB2 →	+3.930	+3.632	.003	.003	1	3
OVARY	SMTN →	+4.345	+4.345	<.001	<.001	1	3
STOMACH	ARHGEF10 →	+3.942	+4.584	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,293 associations by consensus.

TBX2 by HDAC11 expression — OVARY

Explore this box plot interactively →