HDAC11-AS1

Across TCGA pan-cancer cohorts, HDAC11-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HDAC11-AS1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher HDAC11-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HDAC11-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and ESCA show a favorable association.

LIHC, KICH, and BLCA are the cancer types where HDAC11-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	All	0.281	0.576	<.001	44	view →
KICH	OS	Median	III,IV	0.766	1.000	.006	41	view →
BLCA	DFS	Quartile	III,IV	0.598	0.320	.006	19	view →
UCEC	OS	Median	All	0.556	0.822	.016	18	view →
THCA	DFS	Quartile	IV	0.462	0.865	.004	16	view →
ACC	OS	Tertile	IV	0.344	0.724	.038	13	view →
ESCA	OS	Tertile	IV	0.922	0.247	.024	12	view →
UCS	OS	Tertile	IV	0.844	0.268	.042	12	view →
CHOL	DFS	Median	All	0.586	0.212	.015	11	view →
HNSC	OS	Median	II,III,IV	0.555	0.300	.010	11	view →
LUAD	OS	Quartile	II,III,IV	0.413	0.134	.005	7	view →
UVM	DFS	Tertile	All	0.794	0.524	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HDAC11-AS1–LIHC (DFS)

Open the LIHC breakdown →