HDAC10

Across TCGA pan-cancer cohorts, HDAC10 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HDAC10 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HDAC10 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated HDAC10 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, BLCA, and UCEC are the cancer types where HDAC10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.180	0.604	.011	24	view →
BLCA	DFS	Median	All	0.205	0.521	.027	12	view →
UCEC	DFS	Median	All	0.957	0.635	.044	4	view →
LUAD	OS	Median	All	0.241	0.684	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HDAC10–HNSC (DFS)

Open the HNSC breakdown →