HDAC10

Across TCGA cell cohorts, HDAC10 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible HDAC10-associated genes across cancer lineages are OR2D2, CD300LB, and IZUMO1R. Each is linked with HDAC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both HDAC10-to-partner and partner-to-HDAC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D2 grouped by HDAC10-low versus HDAC10-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HDAC10→partner) and Y-score (partner→HDAC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2D2 →	+0.021	+3.938	.009	.005	3	1
OVARY	CD300LB →	+0.030	+4.285	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	DEFB108B →	+0.194	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	1
STOMACH	CYB5R3 →	+0.834	+3.240	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

OR2D2 by HDAC10 expression — OVARY

Explore this box plot interactively →