HCST

Across TCGA pan-cancer cohorts, HCST Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated HCST data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HCST Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HCST expression acts as an unfavorable survival marker.

SKCM and LIHC are the cancer types where HCST Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.202	0.735	.002	16	view →
LIHC	OS	Median	All	0.144	0.688	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

HCST–SKCM (OS)

Open the SKCM breakdown →