HCST

Across TCGA patient cohorts, HCST RNA expression is significantly associated with the protein abundance of many other proteins, with 20,601 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HCST-associated proteins across cancer lineages are RASAL3, RCSD1, and RCSD1_S179. Each is linked with HCST in more than 9 cancer types. Because this analysis shows association rather than direction, both HCST-to-partner and partner-to-HCST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCST versus RASAL3 in OV, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HCST→partner) and Y-score (partner→HCST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RASAL3 →	+0.508	+0.621	<.001	<.001	3	10
LSCC	RCSD1 →	+0.585	+0.750	<.001	<.001	3	10
LSCC	RCSD1_S179 →	+0.731	+0.839	<.001	<.001	3	10
OV	RCSD1_S351 →	+0.928	+0.864	<.001	<.001	3	10
HNSC	SAMHD1 →	+0.463	+0.922	<.001	<.001	3	10
GBM	SASH3 →	+0.616	+0.990	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,601 associations by consensus.

HCST vs RASAL3 — OV

Explore this scatter interactively →