HCST

Across TCGA patient cohorts, HCST protein abundance is significantly associated with the RNA expression of many other genes, with 8,051 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HCST-associated genes across cancer lineages are TNS3, CLEC4D, and ANPEP. Each is linked with HCST in more than 4 cancer types. Because this analysis shows association rather than direction, both HCST-to-partner and partner-to-HCST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCST versus TNS3 in BRCA, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCST→partner) and Y-score (partner→HCST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TNS3 →	+1.949	+0.941	<.001	.001	3	5
LSCC	CLEC4D →	+0.567	+0.437	.001	.001	3	4
PDAC	ANPEP →	+1.357	+0.404	<.001	<.001	3	4
GBM	ATP8A2 →	-0.777	-0.344	.003	.003	3	3
GBM	BLCAP →	-0.446	-0.427	<.001	.007	3	3
GBM	OTUD7A →	-0.757	-0.411	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,051 associations by consensus.

HCST vs TNS3 — BRCA

Explore this scatter interactively →