HCST

Across TCGA patient cohorts, HCST mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCST-associated genes across cancer lineages are TTTY7B, MIRLET7G, and RNU6-753P. Each is linked with HCST in more than 1 cancer types. Because this analysis shows association rather than direction, both HCST-to-partner and partner-to-HCST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY7B grouped by HCST-low versus HCST-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCST→partner) and Y-score (partner→HCST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTTY7B →	+0.024	+8.471	<.001	.005	3	2
UCEC	MIRLET7G →	+0.657	+3.334	<.001	.008	3	1
UCEC	RNU6-753P →	+0.804	+6.060	<.001	<.001	3	1
UCEC	CD300LD →	+0.163	+4.046	.003	.003	3	1
UCEC	RNU6-431P →	+0.916	+3.675	.001	.007	3	1
UCEC	RNU1-138P →	+0.293	+3.418	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

TTTY7B by HCST expression — BRCA

Explore this box plot interactively →