HCST

Across TCGA cell cohorts, HCST RNA expression is significantly associated with the go_rna of many other GO terms, with 2,876 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HCST-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and ERAD pathway. Each is linked with HCST in more than 7 cancer types. Because this analysis shows association rather than direction, both HCST-to-partner and partner-to-HCST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by HCST-low versus HCST-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCST→partner) and Y-score (partner→HCST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of myoblast fusion →	+0.119	+0.803	<.001	<.001	3	8
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.109	+0.803	<.001	<.001	3	8
KIDNEY	ERAD pathway →	+0.049	+0.340	.002	.007	3	8
KIDNEY	Cellular response to unfolded protein →	+0.064	+0.259	.002	.006	3	7
KIDNEY	Response to unfolded protein →	+0.065	+0.270	.007	.004	2	8
OESOPHAGUS	Exploration behavior →	+0.105	+0.331	<.001	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,876 associations by consensus.

Negative regulation of myoblast fusion by HCST expression — OVARY

Explore this box plot interactively →