HCRTR2

Across TCGA patient cohorts, HCRTR2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCRTR2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Bap1-c-4, and Cyclin-B1. Each is linked with HCRTR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HCRTR2-to-partner and partner-to-HCRTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by HCRTR2-low versus HCRTR2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCRTR2→partner) and Y-score (partner→HCRTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	p38-MAPK_pT180_Y182 →	-0.488	-3.321	.003	.009	3	4
LUAD	Bap1-c-4 →	+0.193	+2.338	.033	.019	2	4
UCEC	Cyclin-B1 →	+0.752	+2.906	<.001	.001	3	3
UCEC	PCNA →	+0.247	+1.925	.001	.005	3	3
UCEC	Annexin_VII →	-0.136	-1.584	.006	.019	3	3
UCEC	STAT3_pY705 →	-0.463	-2.415	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

p38-MAPK_pT180_Y182 by HCRTR2 expression — LUAD

Explore this box plot interactively →