Across TCGA patient cohorts, HCP5 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCP5-associated genes across cancer lineages are STAT3_pY705, FoxM1, and INPP4B. Each is linked with HCP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCP5-to-partner and partner-to-HCP5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCP5→partner) and Y-score (partner→HCP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.454	-3.459	<.001	.005	3	2
UCEC	FoxM1 →	+0.289	+3.459	.026	.005	3	1
UCEC	INPP4B →	-0.336	-2.308	.039	.036	3	1
UCEC	JNK2 →	+0.322	+3.179	.001	.010	3	1
UCEC	VHL →	-0.970	-3.169	.004	.019	3	1
UCEC	Caspase-8 →	-0.258	-3.143	.041	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

HCP5 survival (RNA) · tumor vs normal (RNA) · all HCP5 data types