HCN4

Across TCGA pan-cancer cohorts, HCN4 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated HCN4 data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HCN4 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated HCN4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, ESCA, and BLCA are the cancer types where HCN4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.937	0.452	.011	30	view →
ESCA	OS	Median	All	0.156	0.704	<.001	27	view →
BLCA	OS	Median	IV	0.130	0.599	.002	12	view →
HNSC	OS	Median	All	1.000	0.652	.017	8	view →
LAML	DFS	Median	All	0.140	0.572	.040	6	view →
SKCM	DFS	Median	IV	0.040	0.454	.028	6	view →
DLBC	OS	Median	All	0.613	0.945	.049	3	view →
LIHC	OS	Median	All	1.000	0.492	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

HCN4–UCEC (OS)

Open the UCEC breakdown →