HCN4

Across TCGA patient cohorts, HCN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,159 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible HCN4-associated GO terms across cancer lineages are Golgi organization, Protein-containing complex disassembly, and Organelle disassembly. Each is linked with HCN4 in more than 17 cancer types. Because this analysis shows association rather than direction, both HCN4-to-partner and partner-to-HCN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi organization grouped by HCN4-low versus HCN4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN4→partner) and Y-score (partner→HCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Golgi organization →	+0.058	+0.319	<.001	<.001	3	18
STAD	Protein-containing complex disassembly →	+0.058	+0.287	<.001	<.001	2	18
ESCA	Organelle disassembly →	+0.052	+0.284	<.001	<.001	3	17
SCLC	Positive regulation of double-strand break repair →	+0.067	+1.142	<.001	<.001	3	17
STAD	Golgi vesicle transport →	+0.073	+0.210	<.001	.001	3	17
ESCA	Establishment of protein localization to membrane →	+0.063	+0.492	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,159 associations by consensus.

Golgi organization by HCN4 expression — ESCA

Explore this box plot interactively →