HCN4

Across TCGA patient cohorts, HCN4 protein abundance is significantly associated with the RNA expression of many other genes, with 13,391 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HCN4-associated genes across cancer lineages are RANBP9, RNF24, and TRIB3. Each is linked with HCN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCN4-to-partner and partner-to-HCN4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCN4 versus RANBP9 in GBM, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN4→partner) and Y-score (partner→HCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RANBP9 →	+0.495	+0.843	<.001	.001	3	1
GBM	RNF24 →	+0.637	+0.913	.001	.001	3	1
GBM	TRIB3 →	+1.325	+1.066	<.001	<.001	3	1
GBM	KIF3B →	+0.341	+0.982	<.001	<.001	3	1
GBM	SLC30A4 →	+0.397	+0.869	.006	<.001	3	1
GBM	BLOC1S6 →	+0.571	+1.018	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,391 associations by consensus.

HCN4 vs RANBP9 — GBM

Explore this scatter interactively →