HCN4

Across TCGA cell cohorts, HCN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,348 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible HCN4-associated GO terms across cancer lineages are Cardiac muscle cell action potential, Regulation of heart contraction, and Tyrosine phosphorylation of STAT protein. Each is linked with HCN4 in more than 6 cancer types. Because this analysis shows association rather than direction, both HCN4-to-partner and partner-to-HCN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cardiac muscle cell action potential grouped by HCN4-low versus HCN4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN4→partner) and Y-score (partner→HCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Cardiac muscle cell action potential →	-0.104	-0.217	.001	.001	3	7
OESOPHAGUS	Regulation of heart contraction →	-0.098	-0.430	<.001	.005	3	6
STOMACH	Tyrosine phosphorylation of STAT protein →	-1.391	-0.580	<.001	.009	3	5
OESOPHAGUS	Cardiac muscle cell contraction →	-0.119	-0.364	.001	.004	3	5
OESOPHAGUS	Ventricular cardiac muscle cell action potential →	-0.159	-0.431	.003	.005	3	5
OESOPHAGUS	Regulation of heart rate by cardiac conduction →	-0.248	-0.446	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,348 associations by consensus.

Cardiac muscle cell action potential by HCN4 expression — OVARY

Explore this box plot interactively →