HCN4

Across TCGA cell cohorts, HCN4 mutation is significantly associated with the RNA expression of many other genes, with 429 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HCN4-associated genes across cancer lineages are HMGXB4, RWDD2A, and MED9. Each is linked with HCN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCN4-to-partner and partner-to-HCN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGXB4 grouped by HCN4-low versus HCN4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN4→partner) and Y-score (partner→HCN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HMGXB4 →	+0.482	+2.850	.005	<.001	3	2
LARGE_INTESTINE	RWDD2A →	+0.469	+3.169	<.001	.009	3	2
LARGE_INTESTINE	MED9 →	+0.450	+2.244	.001	.003	3	2
LARGE_INTESTINE	COPS3 →	+0.513	+3.949	.004	<.001	3	2
LARGE_INTESTINE	FEM1A →	+0.511	+2.158	.001	.004	3	2
LARGE_INTESTINE	MMS22L →	+0.694	+3.087	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 429 associations by consensus.

HMGXB4 by HCN4 expression — LARGE_INTESTINE

Explore this box plot interactively →