HCN3

Across TCGA patient cohorts, HCN3 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,829 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HCN3-associated proteins across cancer lineages are NELFCD, TRRAP, and DHX9. Each is linked with HCN3 in more than 6 cancer types. Because this analysis shows association rather than direction, both HCN3-to-partner and partner-to-HCN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HCN3 versus NELFCD in LSCC, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN3→partner) and Y-score (partner→HCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NELFCD →	+0.277	+0.621	<.001	<.001	3	7
LSCC	TRRAP →	+0.214	+0.696	<.001	<.001	3	7
LSCC	DHX9 →	+0.311	+0.881	<.001	<.001	3	7
GBM	HNRNPU →	+0.278	+0.736	<.001	<.001	3	7
LSCC	AQR →	+0.361	+0.856	<.001	<.001	3	6
LUAD	NAXE →	+0.378	+0.640	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,829 associations by consensus.

HCN3 vs NELFCD — LSCC

Explore this scatter interactively →