HCN3

Across TCGA patient cohorts, HCN3 mutation is significantly associated with the RNA expression of many other genes, with 1,831 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCN3-associated genes across cancer lineages are RNA5SP248, MIR1302-5, and RNU7-176P. Each is linked with HCN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both HCN3-to-partner and partner-to-HCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP248 grouped by HCN3-low versus HCN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN3→partner) and Y-score (partner→HCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP248 →	+0.264	+1.569	.001	.006	3	4
BRCA	MIR1302-5 →	+0.500	+5.116	<.001	.001	3	3
UCEC	RNU7-176P →	+0.276	+2.492	<.001	.001	3	3
COAD	TRAJ50 →	+0.926	+5.478	<.001	<.001	3	3
UCEC	CENPU →	+0.664	+2.628	<.001	.005	2	3
UCEC	C19orf47 →	+0.323	+1.546	.006	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,831 associations by consensus.

RNA5SP248 by HCN3 expression — UCEC

Explore this box plot interactively →