HCN3

Across TCGA patient cohorts, HCN3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HCN3-associated genes across cancer lineages are ATM, EGFR_pY1068, and GAPDH. Each is linked with HCN3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HCN3-to-partner and partner-to-HCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HCN3-low versus HCN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN3→partner) and Y-score (partner→HCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.700	-2.906	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.215	-1.906	.017	.015	3	2
UCEC	GAPDH →	+0.488	+1.906	.011	.015	3	2
UCEC	mTOR_pS2448 →	-0.139	-1.565	.009	.034	3	2
UCEC	P-Cadherin →	-0.158	-3.700	.002	.001	3	2
UCEC	PCNA →	+0.288	+2.321	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by HCN3 expression — UCEC

Explore this box plot interactively →