HCN3

Across TCGA cell cohorts, HCN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,791 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HCN3-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Copper ion export, and Pre-mRNA catabolic process. Each is linked with HCN3 in more than 14 cancer types. Because this analysis shows association rather than direction, both HCN3-to-partner and partner-to-HCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by HCN3-low versus HCN3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN3→partner) and Y-score (partner→HCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.151	+0.887	<.001	<.001	3	15
SOFT_TISSUE	Copper ion export →	-0.202	-1.036	<.001	<.001	3	13
BONE	Pre-mRNA catabolic process →	+0.267	+1.450	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.084	+1.097	<.001	<.001	3	12
BONE	Subtelomeric heterochromatin formation →	+0.113	+1.020	.007	.003	2	13
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.186	+1.286	.005	.002	2	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,791 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by HCN3 expression — SOFT_TISSUE

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