HCN3

Across TCGA cell cohorts, HCN3 mutation is significantly associated with the RNA expression of many other genes, with 329 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HCN3-associated genes across cancer lineages are WFDC12, CST2, and KRTAP6-1. Each is linked with HCN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both HCN3-to-partner and partner-to-HCN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC12 grouped by HCN3-low versus HCN3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HCN3→partner) and Y-score (partner→HCN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	WFDC12 →	+0.106	+2.704	<.001	.005	3	2
LUNG_SCLC	CST2 →	+0.051	+4.817	<.001	.001	3	1
LUNG_SCLC	KRTAP6-1 →	+0.052	+4.643	<.001	.004	3	1
LUNG_SCLC	KPRP →	+0.281	+4.044	.001	.009	3	1
BLOOD_Leukemia	CST4 →	+0.027	+2.450	<.001	.007	3	1
BLOOD_Leukemia	AQP9 →	+1.224	+3.491	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 329 associations by consensus.

WFDC12 by HCN3 expression — BLOOD_Leukemia

Explore this box plot interactively →