HCLS1

Across TCGA pan-cancer cohorts, HCLS1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated HCLS1 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher HCLS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HCLS1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, LUAD, and LAML are the cancer types where HCLS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.143	0.875	<.001	42	view →
LUAD	OS	Median	III,IV	0.116	0.669	<.001	21	view →
LAML	DFS	Median	All	0.028	0.572	<.001	12	view →
LIHC	OS	Median	All	0.144	0.688	.013	9	view →
ESCA	OS	Median	II,III,IV	0.321	0.685	.035	6	view →
SKCM	OS	Median	III,IV	0.245	0.721	.048	3	view →
UCEC	DFS	Median	All	0.959	0.622	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

HCLS1–CESC (OS)

Open the CESC breakdown →